c. 1600, "to cast beams of light upon," from Latin irradiatus, past participle of irradiare "shine forth," from assimilated form of in- "into, in" (see in- (2)) + radiare "to shine" (see radiate). Meaning "expose to radiation other than light" (originally X-rays) is from 1901. Related: Irradiated; irradiating.
